The Premier League's leading goalscorers will be on show at when surprise leaders Leicester City bid to move further ahead at the top with victory against Everton at Goodison Park on Saturday.
Arsenal's new manager Unai Emery faces a baptism of fire after the Gunners were handed an opening day fixture at home to Premier League champions Manchester City.
David Silva scored a late goal as runaway leaders Manchester City won their 13th successive Premier League game and restored their eight-point lead with a 2-1 victory against West Ham United on Sunday.
Liverpool captain Steven Gerrard scored the first hat-trick in a Merseyside league derby since 1982 as his side enjoyed an emphatic 3-0 victory over Everton in the Premier League at Anfield on Tuesday.
Watford's hopes of avoiding relegation suffered a double blow on Tuesday when they were thrashed 4-0 at home by Manchester City and then slipped into the Premier League relegation zone after fellow strugglers Aston Villa beat Arsenal in the late game.
The Premier League title race took another dramatic twist on Sunday when leaders Manchester United blew a two-goal lead to draw 4-4 with Everton and Manchester City beat Wolverhampton Wanderers 2-0 to narrow the gap to three points.
The relegation zone merry-go-round continued when Wigan Athletic beat Everton 1-0 to climb out of the bottom three on Monday. Henri Camara shot in from close range after being set up by Antonio Valencia in the 51st minute before Tim Cahill wasted a glorious late chance to earn Everton a point.
Manchester United battled back from two goals down to beat Newcastle United 3-2 at Old Trafford on Saturday as a 90th-minute winner from Alexis Sanchez completed a spirited comeback to ease the pressure on manager Jose Mourinho.
Photos from the English Premier League matches played on Saturday
News of all that's transpired on and off the football field
Images from the English Premier League matches played on Saturday.
Sergio Aguero believes the 14-point gap between the defending champions and Premier League leaders Liverpool is 'too hard' to overturn
Regardless of whether they eventually win it at home or away, the celebrations that marked their Anfield victory over Queens Park Rangers that won the league in 1990 will not be repeated.
Swansea City came from behind to beat Arsenal 2-1 and Tottenham Hotspur's misery continued with a 2-1 home defeat by Stoke City, making it a nightmare Sunday for north London.
Leicester beat Southampton to open seven-point gap at the top.
Images from the English Premier League matches played on Saturday
English football clubs splurged on the final day of the transfer window, laying out 210 million pounds to take total gross spending to a record-high 1.4 billion pounds as the Premier League again flexed its unrivalled financial muscles.
Manchester City's impressive 2-0 victory at Everton on Sunday equalled a club record of nine successive Premier League wins.
Everton missed the chance to secure a place in next season's UEFA Cup when they were beaten 1-0 by Arsenal in the Premier League on Sunday.
Manchester City have signed England centre back John Stones from Everton as new manager Pep Guardiola continues to reshape his side for the start of the English Premier League season.
Images from Sunday's Premier League action.
Manchester City midfielder Kevin de Bruyne is facing a potentially lengthy spell on the sidelines after he was carried off on a stretcher with a suspected knee ligament injury in Wednesday's League Cup semi-final win over Everton.
Following is a match by match look at the English Premier League's season-opening weekend fixtures:
Tottenham Hotspur's tenacious chase of leaders Chelsea continued as they claimed a 12th consecutive Premier League home win with a 4-0 rout of Bournemouth on Saturday to cut the gap to four points.
Robert Huth's double and a Riyad Mahrez goal sent Premier League leaders Leicester City six points clear after a stunning 3-1 victory at shell-shocked title rivals Manchester City on Saturday.
Tottenham Hotspur beat local rivals Arsenal with second-half goals from prolific pair Dele Alli and Harry Kane on Sunday to maintain their Premier league title challenge.
Tottenham Hotspur and Liverpool raised the spirits with a rip-roaring 2-2 draw in a pre-Christmas Premier League classic on Sunday after a weekend marred by COVID-19 related postponements.
An own goal by Stoke City keeper Jack Butland gifted Leicester City an equaliser in a 1-1 Premier League draw at the King Power Stadium on Saturday and denied Paul Lambert's side a rare win on the road.
Jose Mourinho understands why Manchester United supporters gave Marouane Fellaini a negative reception during Sunday's 1-0 win over Tottenham Hotspur but the manager will do all he can to protect the midfielder.
Arsenal will not sell striker Olivier Giroud, midfielder Jack Wilshere and winger Theo Walcott in the January transfer window despite their lack of playing time at the Premier League club, manager Arsene Wenger has said.
Spain and Portugal played out an entertaining 0-0 draw on Friday as both sides prepared for this month's European Championship.
Two big derbies and an eventful weekend of football awaits us all...
Images from the English Premier League matches played on Saturday
With Liverpool still to visit Chelsea, who trail them by nine points with two games in hand, Juergen Klopp's side may have to beat Brighton & Hove Albion on May 13 and rely on their superior goal difference to qualify for the Champions League, assuming they do not secure it by winning this year's trophy.
Livewire striker Javier Hernandez struck six minutes from time to give Manchester United a 1-0 home win over Everton that extended their Premier League lead to nine points on Saturday.
IMAGES from the Premier League matches played on Sunday.
On Sunday the Ukrainian Tennis Federation urged the sport's governing body the International Tennis Federation (ITF) to immediately expel Russia and Belarus from the organisation and ban Russia from team and individual tournaments. Also, athletes from Ukraine and other nations have called on the International Olympic Committee (IOC) to suspend Russia and Belarus and ban their athletes from events immediately.
Manchester City came from behind twice to earn a 2-2 draw with Liverpool in a breathless and pulsating Premier League encounter, at Anfield, on Sunday. All four goals came in the second half.
All elite soccer matches in England, including the Premier League, were suspended until April 4 on Friday due to the coronavirus pandemic, English soccer's governing bodies said. The decision to suspend all football activity in the country had been jointly taken by the Premier League, the FA, the EFL and the Women's Super League (WSL), it added.
Here are five talking points from the weekend's action:
